Anti-irritation & Allergy Soothing Compound

Description: the anti-irritation and allergy soothing compound is composed of various high-efficiency natural active matters extracted from plants and microbes. With the collaboration of these active matters, it has the activity of anti-irritation, anti-inflammation, anti-bacteria, facilitating injury recovery, improving skin immune, soothing allergies, etc., and can be widely used in skincare products designed for acne skin, sensitive skin, etc.

 

Applications:

  • Skin care products for the treatment of acne skin
  • Products for infants and children
  • Products for sensitive skin
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    Use of Product:add it at ordinary temperature stage; recommended dosage: 0.5-5%. Avoid high-temperature processing to prevent inactivation

    Storage of Product: keep it away from light at a temperature below 25℃.

     

    Magnano Magnolia officinalis Extract Nanoemulsion

    Magnolia officinalis is an important herb of traditional Chinese medicine, which has been included in the Chinese pharmacopoeia. Magnolia officinalis barks contain two anti-inflammatory isomers, magnolol and honokiol. Magnolia officinalis barks have been used in Asia for more than a thousand years in the treatment of qi stagnation (lassitude), digestive disorders, anxiety, and allergic diseases. Magnolia officinalis extract nanoemulsion uses nano-technology to encapsulate magnolol and honokiol, the main active matters of magnolia officinalis extract, to solve the problem of solubility, making it more stable and easier to be absorbed so that it can better perform its activity of anti-inflammation, anti-aging, anti-aging, anti-bacterial, etc.

     Magnolol and honokiol                                    a traditional Chinese medicine Magnolia officinalis

    Wide Application of Magnolia Officinalis Extract in Medicine

    Inflammation is the first body response to infection or irritation, manifested by partially increased blood flow, migration and activation of immune cells in the affected area, release of numerous free radicals, and destruction towards normal tissues. Ideally, inflammation can clear the infection and then resolve spontaneously, allowing normal tissues to rebuild. But inflammation can become chronic (for example, the infection does not completely disappear, or the inflammatory response becomes very sensitive, or the inflammatory response is caused by an autoimmune response). In addition, as we grow older, we are more and more prone to chronic inflammation. Chronic inflammation caused by free radicals will particularly accelerate the aging process.

    Inflammation Caused by Free Radicals

           Chronic inflammation is a key risk factor as we age, and it is now considered as one of the key risk factors for aging diseases such as heart disease and stroke. Inflammation is also deemed as the cause of some age-related common neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Studies have found that when a person is feeble, there is usually an excess of one or more inflammatory factors inside him, such as TNF-a (tumor necrosis factor), IL-6, IL-1 (b), or IL-8 (leukocyte hormone). Inflammatory aging becomes a major challenge for human health.

     

    Inflammatory Aging

    Studies have shown that the main active matters in the magnolia officinalis extract are magnolol and honokiol. Magnolol and honokiol are effective in removing oxygen free radicals from the body. By inhibiting the activation of NF-ĸB (transcription factor), magnolol and honokiol produce a synergistic anti-inflammatory effect. In addition, they have antioxidant, antibacterial and anti-angiogenic effects while reducing harmful substances. Magnolol and honokiol also have a very strong anti-allergic effect.

    Magnolia officinalis has strong antibacterial effect. Its antibacterial spectrum is wide, and the antibacterial property is stable, which will not be easily damaged by heat, acid and alkali. It has a strong inhibitory effect on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, etc., and has an inhibitory effect on common pathogenic skin fungi.

    Better Anti-propionibacteria Activity of Magnolol and Honokiol than Erythromycin

     

    Minimum Inhibitory Concentration (MIC) of Magnolol and Honokiol against Propionibacterium

    Higer Transdermal Efficiency of Nanoemulsion Encapsulated Active Matters than Traditional Preparations

    Product Features:

  • Magnano uses materials of FDA GRAS class, so it is very safe
  • Magnano is stable to heat, pH and cuts, so it is convenient to use
  • Magnano greatly improve the solubility, stability and bioavailability of plant polyphenols.
  • Magnano can improve the stability of other active matters in the product and facilitate absorption
  • Magnano itself has good antibacterial activity without preservatives
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    Wide Application of Magnano in Skincare Products

    Use of Product:Add it at a low temperature. It is suitable for anti-aging, anti-inflammation, anti-oxidation products, etc.

    Recommended dosage:0.1-5%。Better effect with products containing nano-astaxanthin, etc.

    Storage of Product: keep it away from light at a temperature below 25℃.

     

    Synbiotics Skin Micro-ecological Nanoemulsion BioNanoCare

    A perfect match of biopharmaceutical technology and nanotechnology

    Description: With the rise of skin microbiology, the combination of probiotics and prebiotics (i.e., Synbiotics) targeting the removal of bacteria harmful to skin with targets has been the latest trend in the materials of international skincare and skincare products. BioNanoCare is a nano-encapsulated synbiotic designed for the skin micro-ecological balance and skin repair, using modern biological and nano-technology, combined with probiotics and prebiotics, and targeting bacteria harmful to skin. With advantages of safety, high efficiency and environmental friendliness, it will not kill good bacteria together with bad ones like traditional antibiotics. The nano-encapsulated probiotics extract can provide nutrients and moisture for skin repair, thereby moisturizing, preventing aging and wrinkles and inhibiting pigmentation, so that the skin will return to normal. The nano-encapsulated prebiotics can effectively promote the proliferation of probiotics on the skin surface, thereby inhibiting the growth of harmful bacteria, restore the micro-ecological balance of skin as soon as possible, and keep the skin young. Specially added water-soluble yeast glucan can effectively activate skin Langerhans cells, and play a role in anti-inflammation, anti-allergy, eliminating the activity of radicals, moisturizing and accelerating the renewal of the stratum corneum, helping the skin resist external exogenous various mechanical and chemical stimuli and promoting the recovery of injuries.

    Saccharomyces cerevisiae           Fructo oligosaccharide                 Lactobacillus

    Fungi, bacteria and viruses on the surface of human skin constitute a complex microbial ecosystem called the “skin microbiome”. Microbiome study is becoming popular in the biomedical field. In May 2016, the White House announced the launch of the National Microbiome Initiative (NMI), aiming to promote the development of microbial science, benefiting individuals, communities and all of humanity in the areas of health care, food production, environmental protection, etc. As a hot theme in biomedicine, microbiome is expanding into the field of skin research. The international renowned pharmaceutical company Johnson & Johnson also announced the establishment of the Johnson & Johnson Human Microbiome Research Center in February last year. In recent years, the company has endeavored a lot to develop the role of microbiome in the development of new drugs. It is reported by Happi that Johnson & Johnson Consumer Inc. has reached an agreement with Xycrobe Therapeutics, a US biotechnology startup, to further cooperate on the treatment of inflammatory skin diseases.

    The research team led by the National Institute of Allergy and Infectious Diseases (NIAID) published an article in Nature(Jan 5, 2015), stating that the skin microbiome can significantly affect immunity. The researchers transplanted different types of symbiotic bacteria into mice to prompt them to produce specific immune cells of symbiotic bacteria. After the transplantation of S.epidermidis, a common skin symbiotic bacterium, onto the skin of mice, the number of CD8+T cells is increased, and this immune cell can produce the chemical messenger IL-17A. Studies have shown that Staphylococcus epidermidis can enhance immunity to specific pathogens without causing inflammation. Different types of skin symbiotic bacteria can cause different immune responses, which indicates that immune cells in skin can quickly sense and respond to changes in the skin flora. These findings help explain the protective role of skin symbiotic bacteria and to reveal the specific mechanisms of how flora changes cause skin diseases.

    Human Skin Microbial Map

    The paper “Temporal Stability of the Human Skin Microbiome” published in Cell(May 5, 2016) reported a new metagenomic study which shows that despite frequent cleaning and exposure to bacteria-rich objects, our individual skin microbial environment remains highly stable after a period of time. This recognition can be used to better understand a range of human skin diseases, thus helping to develop prebiotic, probiotic and microbial transplantation.

     According to a survey of the World Health Organization (WHO), among the yellow races, people whose skin is in a healthy state account for less than 10%, more than 20% are in a morbid state, and 70% are in a sub-healthy state. The past 30 years has seen the significant growing trend of skin diseases in the world. The abuse of antibiotics and hormones has led to more and more skin diseases caused by the environment, e.g., eczema, acne, hormonal dermatitis, cosmetic-dependent dermatitis, seborrheic dermatitis, etc. With the development of biomedicine, the study found that 95% of skin diseases show a skin micro-ecological imbalance. ​

    Micro-ecological balance refers to the dynamic balance of normal combination of normal micro-organisms and their host ecosystems during the long-term evolution process. On the surface of the normal person, i.e., on the surface of the skin and internal parts, there are numerous microorganisms. The floras on the skin surface is divided into resident and temporary ones, most of which are beneficial to our body, such as clearing the waste on the skin surface (apoptotic cells), decomposing excessive lipids, resisting the invasion of foreign pathogens through competitive inhibition, etc. When the balanced relationship is broken, the skin function will be disordered, which causes diseases. Therefore, the Human Microbiological Program funded by the National Institutes of Health has been implemented to explore the characteristics and role of human micro-ecology. Recently, researches on skin micro-ecology have also received increasing attention from dermatologists. The balance and stability of floras have an important impact on the physiological function of bodies. The balance and stability of the in vivo floras directly affects the barrier effect of the skin surface on the external defense, and can obviously promote the balance of floras and improve the immunity.

    Billions of bacteria that inhabit human bodies form a tiny ecosystem, which is necessary for maintaining normal human growth. Guts, oral cavity, skin and vagina are the four major bacteria banks of human bodies. Various and numerous bacteria are included, hundreds of which have been separated and identified.

    Skin Microbes – an Important Part of the Skin Barrier

     

    Probiotics, the concept of which originates from Greek, means “for life”. In short, probiotics are often called “friendly bacteria” because they play a role in good health by supplementing an appropriate amount of them. There are 10 trillion bacteria in a human body, weighing approx. 1.5 kg. The bacteria include both harmful and beneficial ones. The beneficial ones, also known as probiotics, are friendly bacteria that are good for your health. They enhance and maintain the natural balance of micro-ecology, which is a very important balance for general health and immune system as well. The beneficial bacteria or fungi in human and animal bodies are mainly: bifidobacteria, lactic acid bacteria, Clostridium butyricum, Lactobacillus acidophilus, saccharomycete, etc.

     

     

     

    Skin Micro-ecological Balance

    Studies have shown that the use of microorganisms to stimulate the development of the Th1 immune system and supplement probiotics can effectively stimulate immune cells to produce interferon, IL-10 and other cytokines, improve sensitive constitution and immunity. Probiotic therapy is a safe and effective method for the treatment of eczema. Probiotics can significantly promote the development and maturation of the immune system as well as the injury recovery, change sensitive constitution, gradually reduce the frequency and degree of allergic attacks until they disappear, fundamentally regulate the sensitive constitution, enhance immunity, and thoroughly treat allergic diseases. Nanoemulsion is a new type of safe and effective immune adjuvant. Synbiotic nanoemulsion can better enhance the immune regulation and repair capacity of probiotics.

    In theory, human guts, oral cavity, skin and other tissues and organs all contain bacteria. Moreover, probiotics and harmful bacteria coexist. If there are more probiotics, the proportion of harmful bacteria will be less, and vice versa. Supplementing probiotics is the safest, the most direct and effective method for detoxification and beauty. It can inhibit the growth of harmful bacteria and reduce the production of toxins. Probiotics can gradually restore the partial micro-ecological balance of skin, resist the invasion and growth of harmful bacteria, reduce skin’s absorption and deposition of pigment, make the pigmentation fade away, and solve cosmetic problems from within. It also has a positive therapeutic effect on the treatment of acne, chloasma and other skin diseases. A growing number of studies have shown that skin microbes can promote the skin barrier and natural barrier to form a perfect balance so as to maintain the skin health.

    Micro-ecological adjustment to solve skin problems – handle bacteria with bacteria

     

    Prebiotics can have a positive effect on the hosts and improve the health of hosts by selectively stimulating the growth and activity of one or several bacteria. Prebiotics only proliferate bacteria (probiotics) that are beneficial to humans, but do not proliferate harmful bacteria that have potential pathogenic or spoiling activity to humans. In general, prebiotics are the “nutrition” of human probiotics. Therefore, the addition of high-quality prebiotics to skincare products can help the skin recover and maintain a micro-ecological balance, thus ensuring normal skin barrier function.

    Synbiotics can promote the growth of beneficial bacteria and inhibit the growth of harmful bacteria

    “Synbiotics” refers to the combination of probiotics and prebiotics. The combination of nano-encapsulated prebiotics and probiotic strains produces a synergistic effect that leads to more physiological benefits. The nano-encapsulated probiotic extract can provide nutrients and moisture for skin repair, thereby moisturizing, preventing aging and wrinkles and inhibiting pigmentation, so that the skin will return to normal. The nano-encapsulated prebiotics can effectively promote the proliferation of probiotics on the skin surface, thereby inhibiting the growth of harmful bacteria, restore the micro-ecological balance of skin as soon as possible, and keep the skin young. Synbiotics can also promote the expression of endogenous cationic antibacterial peptides (β-defensins) hBD2 and hBD3. β-defensins can directly bind to the surface of pathogens and destroy them, and prevent the invasion of certain viruses. Cellular test results showed that 0.5% BioNanoCare could promote the expression of hBD2 gene by 51%. In vitro biological tests found that 3% BioNanoCare could promote the expression of hBD3 gene by 72%.

     

    The hair follicles and sweat glands are moist and nutritious, making them ideal for microbial enrichment. The nano-encapsulated synbiotics facilitate the entry of probiotic active matters and prebiotics, promote the growth of beneficial microbes, inhibit the growth of harmful microbes, thus maintaining the skin micro-ecological balance and a good skin barrier function.

    Special Hair Follicle targeting Effect of Nanoparticle Preparations

    The smaller the particle size is, the stronger the adhesion effect is. Nanoparticles can form a good occlusion effect on the skin and increase the moisturizing performance of skin

    Unique Closure Effect of Nanoparticle Preparations

    Yeast is relatively early applied by humans, and is the most widely used microbe. People often use its fermentation to produce a variety of fermented food and wine. Meanwhile, yeast is also a multi-biological therapeutic drug, which is included in the monograph written by the German Commission E (the German statutory herbal pharmacopoeia) as an antibacterial and anti-inflammatory herb that treats acnes. In recent years, the biochemical technology has been developing continuously, especially the progress of fermentation technology. It has continuously produced high-efficiency and innovative yeast extracts. Their most prominent functions are anti-aging, deep repair, skin regeneration and anti-UV protection, anti-allergy soothing, etc. The β-glucan in the yeast wall is a key substance for yeast to exert antibacterial and anti-inflammatory effects.

    Schematic Diagram of Yeast β-glucan Structure

    In the epidermis, the immune system of skin includes plasma cells, Langerhans cells, and keratinocytes. In recent years, Langerhans cells have been confirmed to have a very special relationship with macrophages in the skin, and play an extremely important role in skin immunity. There are many immune networks composed of Langerhans cells under the stratum corneum of the skin. Langerhans cells are dendritic cells, and their antennae can reach the stratum corneum cells with the receptor CR3 of yeast β-glucan. The binding of glucan to the receptor causes a series of stereo chemical changes that activate macrophages, produce various cytokines (e.g., IL-1, IL-6, GM-CSF), epidermal growth factor (EGF), tumor necrosis (TNF-α) and angiogenic factor (AF). On aging or wrinkled skin, an increase in epidermal growth factor can promote the production of collagen and elastin, thus improving the exterior of skin and eliminating small wrinkles.

    Schematic Diagram of the Biological Activity of Yeast Glucan

    Studies have also shown that UV radiation has an inhibitory effect on Langerhans cells in the skin. If the skin is exposed to the sun for a long time, the number and activity of Langerhans cells will be greatly reduced, and the defense immunity of skin will be weakened. In addition to its own sunscreen effect and the ability to relieve pain and inflammation, β-glucan can also promote the proliferation of Langerhans cells and enhance skin immunity. Clinical studies have also shown that yeast glucan plays a role in anti-inflammation, anti-allergy, eliminating the activity of radicals, moisturizing and accelerating the renewal of the stratum corneum, helping the skin resist external exogenous various mechanical and chemical stimuli and promoting the recovery of injuries. Experiments have proved that yeast glucan can significantly reduce the skin allergic inflammation caused by stimulating active ingredients such as fruit acids.

    Healing Effect for Couperose Skin

    Healing Effect for Rashes

    Application of BioNanoCare in Cosmetics

    BioNanoCareis made from natural raw materials so it is non-toxic and non-irritating. It is added to skincare products to help rebuild or maintain good skin micro-ecology and skin barrier, reduce irritation, renew and repair stressed skin, effectively reduce skin wrinkles, improve skin moisture retention and smoothness, promote the recovery and regeneration of scars, brighten the skin, and treat specific dermatitis. It is widely used in anti-wrinkle and anti-aging products, sunscreen and after-sun care products, soothing products for sensitive skin and other high-end cosmetics.

    Instruction for Prescription

    Solubility: This product is easily soluble in water.

    Recommended dosage: The product is added in an amount of 1-10%. It is recommended to add this below 50℃in the final stage of cosmetic production. It is compatible with a wide range of cosmetic ingredients.

     

    BioActive Sugar

    Glycoin® natural is a main active element of myrothamnus flabellifolia
    , which is necessary for it to survive in a long drought.Glycoin® natural revives myrothamnus flabellifolia — it can activate the cells in the long drought (up to 50 years!), and bring a new life to the myrothamnus flabellifolia.

    Glycoin® natural can also be produced by halotolerant blue-green algae, and protect bodies from the damage of osmotic pressure.

    Glycoin® natural
    1. It protects cell membranes and structures from variation and damage
    2. It is featured with an excellent moisture-retaining capacity — even if the humidity of habitats is low, the water in cells still exists.

    When the lipid bilayer is dehydrated, small molecule solutes like glycoin® natural can lower the addition value of temperature during the fluid-gel conversion. This may be explained with the effect of distance among membranes. How do small molecule solutes affect the interaction among membranes is mainly connected with water.
    • As concentration of glycoin® natural rises, the osmotic pressure increases as well. Under the negative water potential, high osmotic pressure can reduce suction force so that the water loss among membranes decreases. The average distance among membranes is enlarged, while the hydration force shrinks.
    • The solutes between bilayers during dehydration also has effect concerning volume: In case of extremely low water content, the molecular volume of glycoin® natural can increase the distance betwwen bilayers, thus reducing the hydration force among membranes.
    • Hence, during weak hydration, such small molecule solutes as glycoin® natural have high concentration and reduce the stress and strain of cell membranes, i.e., the trend of cell membranes turning into colloid declines.

    Natural cell activators
    are featured with strong activating effect and regeneration capacity:
    •enhance cell vigor and metabolism
    •activate regenerative skin cells
    •improve the anti-oxidation of skin cells (sod)
    •accelerate the synthesis of collagen precursor I in aging cells
    •increase the moisture-retaining capacity, elasticity, smoothness and thickness of skin (in vivo tests)
    •relieve the skin redness and resist rash (in vivo tests)
    •facilitate the recovery of injuries and tissue.

     

    PuriBifido

    INCI Name :Bifida Ferment Lysate

    Bifida Ferment Extract, Phenoxyethanol, Potassium Sorbate, Xanthan Gum

    CAS No. None for now; 122-99-6; 24634-61-5; 11138-66-2

    It is fermented by the compound bifidobacteria (known as bifidus yeast in the industry). It is a probiotic product that thoroughly improves the skin condition and can be classified as a skin micro-ecological active matter. The core ingredient of the Estee Lauder Advanced Night Repair is the bifidus yeast. The anti-ageing active ingredients extracted from the lysate of bifidobacteria through biotechnology can effectively protect skin, reduce the damage caused by ultraviolet rays to the skin, activate the immuno-suppressive process, stimulate endogenous skin protection, and promote cell repair. It can reduce skin spots, brighten the skin, reduce the number and degree of wrinkles, and smooth the skin. Bifidus yeast can promote cell repair and support the endogenous protection mechanism to fight against skin aging.

    PuriBifido is created through the fermentation of composite bifidobacterium (commonly known as Bifida) groups. It is a bifidobacterium derivative that can completely improve skin states with the

    Specification

    Exterior
    Opaque light yellow fluid
    Smell
    Slight featured acid smell
    pH
    4.0~6.0
    Total solids
    ≥ 3.0 %
    Nitrogen level
    0.1~0.15%
    Total amount of fungi
    ≤ 50 CFU/ml
    Total amount of bacteria
    ≤ 300 CFU/ml
    Heavy metal
    ≤ 40 ppm

    Recommendation for use

    Recommend dosage: 5.0~20.0%. An addition may be applied if required.

  • This product is a suspension, so there may be a few sediments after being left still for a long time, which is normal. Please shake it up before use.
  • It is recommended to add thickener in the prescription so as to prevent bacteria pieces from subsiding. The specific prescription shall be determined after testing.
  • Use it at the temperature lower than 60℃, and add it to the aqueous phase.
  • If this product is mixed with high-concentration alcohols, the flocculation precipitation will occur. The maximum allowable alcohol concentration is 30% according to the prescription.
  • If this product contacts a strongly acidic/alkaline environment, the flocculation precipitation and color change will occur. It should be avoided to directly add the product to such environment.
  • Rosewood extract nanoemulsion (pTeroNano)

    Pterocarpus Santalinus Wood Extract Nanoemulsion

     

    Being a precious kind of wood, rosewood can be developed for skincare. It has been recorded in Shizhen Li’s “Compendium of Materia Medica” in the Ming Dynasty as a valuable Chinese herbal medicine that helps blood circulation and removes blood stasis. Study has found that pterostilbene is one of the most important active ingredients in rosewood. Pterostilbene is a structural homologue of resveratrol. Recently, it has been found to increase the activity of Sirtuin 1 (deacetylase) by 12 times, which helps delaying aging and prolonging lifespan. Compared with resveratrol, pterostilbene can be more easily absorbed, with good bio-pharmaceutical response, more stable metabolism, stronger effects of anti-oxidation and anti-cell proliferation, a longer half-life (over 7 times that of resveratrol), better clinical effect. It can better reduce NF-κB, iNOS and other anti-inflammatory markers. It can also selectively inhibit COX-2, with an antibacterial ability 5-10 times that of resveratrol. Pterostilbene can effectively inhibit the formation of melanin, brighten the skin, and protect the skin from UV damage. With the pterostilbene nanoemulsion developed by nano-transport system, Puripharm effectively solve the application problems of low solubility, poor stability and easy discoloration so that it can be easily applied to various skincare products.

    Pterostilbene is a derivative in which the third and the fifth of phenolic hydroxyl groups of resveratrol are substituted by methoxy groups. In recent years, it has been increasingly recognized for its potential effects of anti-cancer, anti-oxidation, anti-inflammatory and anti-diabetic. Although the amount and position of the hydroxyl group are usually the main factors determining the biological activity of the natural polyphenol product, pterostilbene, with only the 4-position hydroxyl group, exhibits an antioxidant activity equal to or even stronger than that of resveratrol. In the cell-free system, pterostilbene has an antioxidant capacity similar to that of resveratrol. In terms of protecting erythrocyte membrane from lipid peroxidation, pterostilbene is significantly more effective (IC50 = (44.5 ± 7.8) μmol / L) than resveratrol. Pterostilbene is also known as “second-generation resveratrol”.

                                         Resveratrol                                    Pterostilbene

     

     

     

    Pterostilbene (Pter) is more effective in preventing ultraviolet rays from causing inflammation than resveratrol (Resv).

    Protective effects of Pter and Resv from skin cancer caused by UV irradiation

     

    The main problems hindering Pterostilbene’s application in cosmetics are its chemical instability, discoloration and low solubility. Rosewood extract nanoemulsion developed with nano drug-delivery technologysolves the above problems well while retaining pterostilbene’s intrinsic biological activity. Therefore it can be easily and effectively used in various cosmetics, better absorbed, and function better in whitening, anti-inflammatory and sunburn repair.

    Nanoemulsion is more active than traditional preparations

     

    Product Features

  • pTeroNano uses FDA GRAS grade materials for higher safety.
  • pTeroNano is stable to heat, pH, and cuts, so it is convenient to use.
  • pTeroNano A huge improvement in pterostilbene’s solubility, stability and bioavailability of pterostilbene
  • pTeroNano It can improve the stability of other active substances in the product and facilitate absorption
  •  

    Product use: add under low temperature , pTeroNano has a small amount of positive charge (helps nanocarriers attach to and be absorbed by the skin). If there is much negative charge in the formulation system, you must add pTeroNano before diluting it with pure water, or adjust the dosage, or purchase customized uncharged product from the manufacturer.

    Recommended dosage :0.5-5%。Better effect with products containing nano-retinene, nano-astaxanthin, etc.

    Product Storage: keep it away from light at a temperature below 25℃.

     

    NanoSmooth

    Abstract: NanoSmooth is a new multi-effect skin care active product that developed by using a new type of nanochannel delivery technology which combines anti-inflammatory, anti-itching, and antibacterial healing active compounds such as plant polyphenols and dihydro-o-alkali alkaloids. This skin care active has the functions of repairing barrier, evening skin color, reducing fever and redness, etc

    As people’s awareness of health and environmental protection enhances, active matter derived from plants is getting more and more attention. Plant polyphenols (PPs) are a kind of substance that plants produce to resist natural enemies, competitors, infections and physical injuries. Currently, over 8000 kinds of plant PPs have been discovered. Plant PPs’ abilities of UV absorption, anti-oxidation, radical clearance, metal complexation and antibiosis functions are similar among plants, animals and humans. Many PPs also have the activity of anti-inflammation, anti-allergy, micro-circulation facilitation, anti-tumor, etc., thus are widely being used in fields such as medicine, functional food and cosmeceuticals. The first plant medicine approved by FDA is VEREGEN, a tea polyphenol ointment. The annual sales amount of salvia polyphenol acid salt that Shanghai Green Valley cure cardiovascular diseases through injection has exceeded one billion yuan.

    The unique physical, chemical and biological properties enable the plant PPs to be a natural skin protector against the injuries caused by UV (e.g. inflammation, light aging and canceration) as well as the antibiotics against skin fungus and bacterial infection. Besides, there are many important phenylalanine metabolites in human bodies (e.g. estrogen, thyroxine, tyrosine and dopamine), which are quite similar to the plant PPs derived from phenylalanine. Hence, plant PPs used in human bodies can easily enter the metabolism channel, replacing or competing with endogenous phenylalanine metabolites. This provides a theoretical basis for the plant PPs skincare products that include the functions of brightening, anti-aging, anti-acne, anti-alopecia, brightening and anti-hypertrichosis. As for the anti-inflammation effect closely combined with facilitating the recovery of injuries, not only is it attributed to the anti-oxidation, radical clearance, metal complexation, etc., of plant PPs, but also it depends on the interaction between plant PPs and regular inflammatory cells (e.g. keratinocyte) and collected inflammatory cells (e.g. granulocyte, lymphocyte and dendritic cells) of skin. From the perspective of molecular biology, plant PPs restrain the expression and activation of many pro-inflammatory enzymes by reacting with certain surface receptors, and regulating signal transmission channels and inflammation reaction. The extensive molecular targets make plant PPs become the most promising partly applied active matter for anti-inflammation, anti-allergy and injury recovery. Plant PPs can induce the production of enzymes that eliminate carcinogenic toxin and restrain harmful substance from converting into the final carcinogenic enzymes, thus detoxifying and preventing cancers.

    The main problems that hinder the application of plant PPs in cosmetics are the chemical instability, interaction with other ingredients, low permeability and fast metabolism in skin. NanoSmooth, developed through nano-medicine technology, solves the above problems well while maintaining the original biological activity of the plant polyphenols so that it can be applied to varieties of cosmetics.

    TRPV1 channel, also known as capsaicin receptor, chemical components such as capsaicin, pH<6, temperature>42°C and substance P (SP) can activate the channel, causing cations such as Ca2+inflow and K+outflow. This results in the release of SP and calcitonin gene related peptide (CGRP), causing nociceptive pain [9]. Many TRPV1 channel modulators, including natural products, have been shown to effectively alleviate pain in a variety of animal models, and TRPV1 has become an important target standard for the development of analgesic drugs.

    Capsaicin receptor protein structure

    So far, more than 100 natural regulators targeting TRP channels have been found in nature, including alkaloids, terpenoids, phenols, peptides, flavonoids, etc., involving more than 70 species of animals and plants. Most of the modulators increase or decrease intracellular Ca2+levels by activating or inhibiting TRP channels, resulting in desensitization of nerve endings, induction of endogenous release, etc. Animal tests have demostrated that actives have abilities such as analgesia, anti-inflammation and nervous system protection, etc.

    Scientific research shows that plant polyphenols such as resveratrol and gallnut extract are safe and efficient TRPV1 antagonists, which play an anti-inflammatory and analgesic role. Japanese scientist Yoshihito Shimazu et al. showed that the analgesic effect of partial use topical 10 mM resveratrol is comparable to 37 mM (1%) lidocaine (Brain Research Bulletin, http://dx.doi.org/10.1016/j.brainresbull.2016.06.001).

    NanoSmooth targets TRPV1 target mechanism

     

    Dihydrotomatine alkaloids are derived from the active ingredient of oats (Avenasativa) and have rapid anti-inflammatory and anti-itching activity. Studies have shown that oat alkaloids have multifunctional anti-inflammatory activity, including inhibition of keratinocyte nuclear factor NF-κB-α degradation directly related to inflammation, preventing phosphorylation of p65 protein subunit on nuclear factor NF-κB, thereby blocking the process of breaking cell inflammation; reducing the incidence of inflammatory immune response and skin neurodermatitis. Oat alkaloids inhibit TNF-alpha and induce activity of NF-kappa B degrading enzymes, reduce inflammatory factors and lead to the release of atopic dermatitis IL-8. At a low concentration of 30 ppm, oat alkaloids can greatly reduce the number of itching from contact dermatitis and neurodermatitis. The above evidence indicates that oat alkaloids have potent anti-inflammatory and anti-itch properties and are the potent non-steroidal anti-inflammatory and anti-itching natural ingredient with a potency comparable to hydrocortisone without any side effects of steroid hormones.

    Tranilast is a drug very similar to the structure of dihydroolaline alkaloids and  has powerful effects on: anti-inflammatory, anti-allergic, anti-irritation, fast anti-itching, antihistamine, immunomodulation, anti-fibrosis (anti-scarring), anti-erythema.

    NanoSmooth can exert multiple effects such as antihistamine, anti-oxidation, anti-irritant, anti-inflammatory, and erythema and especially good at relieving sensitive skin, itching, irritation, redness, etc. The recommended dosage range from 0.5% to 5.0%.

    Dihydrotomatine alkaloids and Tranilast structure

     

    NanoSmooth can effectively suppress itching

     

    NanoSmooth can effectively reduce erythema

     

    NanoSmooth can effectively inhibit contact dermatitis

     

    NanoSmooth can effectively inhibit contact dermatitis

     

     

    NanoSmooth developed by nanoChaneel Delivery System(NDS), completely solves the solubility problem of biopolyphenols and dihydrotomatine alkaloids. The active substances are stably encapsulated in nanocarriers, which are convenient for application, difficult to precipitate, and can significantly increase absorption efficiency and bioavailability.

    Use : Adding at the low temperature stage, recommended dosage: 0.5-5.0%.

    Storage: Keep it away from light at a temperature below 25℃.

     

    NanoActive FA

    NanoActive FA is a novel ferulic acid nanoliposome preparation (NanoLiposomal AA).
    Product Name: Nano Liposomal Ferulic Acid; Nanoactive Ferulic Acid; BioaActive Ferulic Acid; BioActive FA; NanoActive FA; Soluble Ferulic Acid

    CAS: 1135-24-6

    Description: Ferulic acid is an organic acid isolated from Ferula foetida regel in 1866. Ferulic acid is an intercellular adhesive that binds the polysaccharides among cells to make the skin firm and elastic. Ferulic acid survives in the blood longer than L-C and is one of the ultimate anti-oxidant warriors. Ferulic acid is a fat-soluble antioxidant. Compared with vitamin E, ferulic acid has a better effect on removing fat-soluble free radicals. The content of ferulic acid is high in Chinese herbal medicines such as Ferula foetida regel, Angelica sinensis, Ligusticum wallichii, Cimicifuga foetida, and seeds of wild jujubes, and it is an active ingredient in these traditional Chinese medicines. It is effective in eliminating free radicals, anti-thrombus, anti-bacteria, anti-inflammation, inhibiting tumor, preventing hypertension, and heart diseases, enhancing the vitality of sperm as well as other health functions and protecting the skin.

     

     

     

     

     

     

     

     

     

     

     

    Ferula foetida regel                                            Ferulic acid

     

    Features

  • NanoActive FA uses FDA GRAS (Generally Recognized as Safe) materials so it is highly safe.
  • NanoActive FA has a good stability towards heat, pH and shearing, so it is easy to use.
  • NanoActive FA greatly improves the stability and bioavailability of ferulic acid.
  • NanoActive FA improves the stability and absorption of other actives in the product.
  • NanoActive FA is 100% water soluble and 100% oil soluble (amphiphilic), allowing a wide range of uses.
  • Efficacy

  • Firming: Combine the polysaccharides among cells to make your skin firmer (sagging eyelids, skin slackness after weight loss and pregnancy)
  • Anti-aging: Confront free radicals (fat-soluble antioxidants)
  • Whitening and evening skin tone: Absorb UVB and inhibit the formation of melanin (whitening by preventing tyrosinase synthesis of melanin through competitive inhibiting method)
  • Use:Add this product at room temperature and heat it to above 40 °C to speed up its dissolution. Recommended dosage: 1-5%. It works better with products such as Nano Vitamin C and Nano Vitamin E.

    Storage: Keep it away from light at a temperature below 25℃.

     

     

    Experimental proof

    Black Cell Producing Effect of Ferulic Acid

     

    Inhibiting Effect of Ferulic Acid against Tyrosinase Activity

     

    Effect of Ferulic Acid on Skin Tone

     

    Effect of Ferulic Acid on Hair