Natural Phospholipid Nano Moisturizer

Description: Natural Phospholipid Nano Moisturizer is a new type of moisturizing lotion developed with natural GMO-free soybean phospholipid, linseed oil, vitamin E and other natural materials under the modern nano-pharmaceutical technology. The average particle size of the product is less than 30nm. With its high transparency and sound stability, it can be applied to various formulations. Small size nanoparticles can have a good Occlusion Effect on our skin, enhancing the ability of moisture preserving of our skin. Phospholipid is one of the main components of human cells. It boasts great biocompatibility and fine skin texture, which provides a natural barrier for our skin against the invasion of external allergens such as microbe and dust particles so as to protect our skin from ultraviolet damage. The interaction between active substance in the formulation and the nano-sized oil dropletscan effectively improve the chemical stability of the product and promote the penetration of the active substance through the corneum into the deep part of our skin, giving full play of its functions and greatly enhancing the quality of the product.

Particles of different sizes interacting with our skin

Journal of Microencapsulation, 2011; 28(8): 709–716

The smaller the particle is, the stronger the adhesion effect is. The nanoparticles can have a good Occlusion Effect on the skin, which enhances the ability of moisture preserving of our skin.

Advanced Drug Delivery Reviews 59 (2007) 522–530

 

Distribution of product particle size

Moisturizing effect of different concentrations of nano moisturizer

Phospholipids (LP)  can effectively reduce skin erythema caused by ultraviolet radiation

Nano moisturizer can promote the absorption and transformation of delta-amino acid in MCF-7 cells

 

Nano moisturizer can promote the transdermal absorption and transformation of delta-amino acid

Acne Nano Concentrate

Description: Natural Compound Acne Nano Concentrate is a new multi-effect acne product developed under various techniques such as plant extraction, biotechnology, green chemistry and nano-encapsulation. It is antibacterial and anti-inflammatory, and also boasts strong ability in anti-oxidation, oil control, pit removing and promoting healing, so it can be widely used in acne, deodorant, pit removing and other products.

  Magnolol                             Honokiol

The main active ingredients of Magnolia Officinalis and Magnolia Officinalis Extract

 

Red Wine Polyphenols – Resveratrol

 

Quercetin and Quercetin

 

 

Quaternary Ammonium Salt-73 (Pionin and Soybean Phospholipids)

 

The antibacterial and anti-inflammatory compound have a strong antibacterial activity against the Gram-positive bacteria:

Microbe
Features:
Minimum inhibitory concentration (MIC)
Propionibacterium acnes
The main pathogen causing acne
0.001-0.0025%
Staphylococcus epidermidis
Normal skin flora, possibility of causing internal infections
0.001-0.0025%
Staphylococcus aureus
Normal skin flora, possibility of causing skin infections
0.001-0.0025%
Corynebacterium jeikeium
Leading to body odor
0.001-0.0025%
Corynebacterium xerosis
Leading to body odor
0.005-0.0025%
Corynebacterium amycolatum
Leading to body odor
0.001%
Streptococcus mutans
Causing tooth decay
0.001-0.0025%
Steptococcus faecalis
Excrement contamination
0.001-0.0025%
Candida albicans
Saccharomycetes, intestinal flora, causing skin infections
0.0005%

 

 

Photos before and after using Natural Compound Acne Nano Concentration skin care products

 

Applications:

  • Skin care products for the treatment of acne skin
  • Products for hidroschesis and deodorization
  •     Use of Product:add it at an ordinary temperature; recommended dosage: 0.5-5%. Better effect with anti-irritation and allergies Relief compound. The anti-acne product will work better with the combination of nano salicylic acid, nano retinaldehyde, nano curcumin, nano azelaic acid and the like.

    Storage of Product: keep it away from light at a temperature below 25℃.

    NS Natural Soluble Yeast Beta-Glucan

    Since the 21st century, scientists have found that the role of polysaccharide in organisms is becoming increasingly important, and that in some respects even exceeds the role of protein, especially in the field of biomedicine. β-glucan takes an extremely essential position, for it is a polysaccharide widely found in bacteria, fungi and higher plants with a stable structure and strong biological activity. In view of sources, it can be divided into yeast glucan, oat glucan, hulless barley glucan, ganoderma champignon glucan, etc. The biological activity of yeast glucan is far superior to the glucan activity of lentinan, Flammulina velutipes Polysaccharide (FVP), krestin (the immune defense system against yeast has been established during human evolution, and CR3 receptors bound to yeast glucan exist on congenital immune cells). The functions of β-glucan in regulating human immunity, anti-tumor, anti-radiation, anti-inflammation, promoting injury recovery, lowering blood fat and blood glucose, anti-aging, etc., have been gradually discovered, catching a widespread concern in the world. In recent years, β-glucan has been widely used in the fields of medicine, food, and personal care products.

    Yeast is relatively early applied by people, and is the most widely- used microbe. People often produce a variety of fermented food and wine by the use of its fermentation. Meanwhile, yeast is also a multi-biological therapeutic drug, which is included in the monograph(the German statutory herbal pharmacopoeia) written by the German Commission E as an antibacterial and anti-inflammatory herb that treats acnes. The β-glucan in the yeast wall is a key substance for yeast to exert its antibacterial and anti-inflammatory effects.

    Yeast glucan is a 1-3, 1-6 linked glucose polysaccharide, which is only present in the yeast cell wall, while the β-(1,3)-(1,6) bond is distributed in a certain proportion. This structure makes it extremely difficult to dissolve in water. The introduction of special chemical radical groups through chemical modification has been a common means to increase water-insoluble macromolecule polymer. The chemical modification process is cumbersome and requires a large amount of organic solvent, and the product is relatively low in safety and environmental friendliness. Moreover, during the improvement of the water solubility of products, the carboxy methylation of yeast β-1,3-D-glucan also has an effect on the three-dimensional structure and biological function of molecules. If the carboxy methylation degree exceeds 75%, molecules will begin losing biological functions, and the complete replacement for the yeast β-1,3-D-glucan molecule will result in a complete loss of its biological efficacy.

    The water-soluble natural glucan developed by molecular chaperones technology solves the disadvantage of chemically modified yeast glucan. Not only does this settle the problem of glucan solubility, but  also it fully retains the three-dimensional structure and biological activity. In this way, it can be easily used as carboxymethyl glucan and oat glucan, yet with higher biological activity.

    Diagram of Yeast β-glucan Structure

     

     

    Mechanism of Yeast β-Glucan

    Combination of Yeast Glucan with a CR3 Receptor on the Surface of a Natural Immune Cell

    Diagram of the biological activity of yeast glucan

    Skin is a very important defense system for humans. It is a natural barrier between human bodies and the outside world, which also has metabolic and immune response functions. In the epidermis, the immune system of skin includes plasma cells, Langerhans cells, and keratinocytes. In recent years, Langerhans cells have been confirmed to have a very special relationship with macrophages in the skin, and play an extremely important role in skin immunity. There are many immune networks composed of Langerhans cells under the stratum corneum of the skin. Langerhans cells are dendritic cells, and their antennae can reach the stratum corneum cells, where the receptor CR3 of yeast β-glucan lives. The binding of glucan to the receptor causes a series of stereo chemical changes that activate macrophages and produce various cytokines (e.g., IL-1, IL-6, GM-CSF), epidermal growth factor (EGF), tumor necrosis factor(TNF-α) and angiogenic factor (AF),etc.. On aging or wrinkled skin, an increase in epidermal growth factor can promote the production of collagen and elastin, thus improving the exterior of skin and eliminating small wrinkles.

    Studies have also shown that UV radiation has an inhibitory effect on Langerhans cells in the skin. If the skin is exposed to the sun for a long time, the number and activity of Langerhans cells will be greatly reduced, and the defense immunity of skin will be weakened. In addition to its own sunscreen effect and the ability to relieve pain and inflammation, β-glucan can also promote the proliferation of Langerhans cells and enhance skin immunity. Clinical studies have also shown that yeast glucan plays a role in anti-inflammation, anti-allergy, eliminating the activity of radicals, moisturizing and accelerating the renewal of the stratum corneum, helping the skin resist external exogenous various mechanical and chemical stimuli and promoting the recovery of injuries. Experiments have proved that yeast glucan can significantly reduce the skin allergic inflammation caused by stimulating active ingredients such as fruit acids.

    Application of yeast β-glucan in cosmetics

    The water-soluble natural β-glucan is derived from natural raw materials and is non-toxic and non-irritating. Adding β-Glucan solution to cosmetics can relieve reduce irritation, renew and repair stressed skin, effectively reduce skin wrinkles, improve skin moisture retention and smoothness, promote the recovery and regeneration of scars, brighten the skin, and treat specific dermatitis. It is widely used in anti-wrinkle and anti-aging products, sunscreen and after-sun care products, soothing products for sensitive skin and other high-end cosmetics.

    Instruction for Prescription

    Solubility: This product is easily soluble in water

    Recommended dosage: The product is added in an amount of 1-10%. It is recommended to add this below 60℃ in the final stage of cosmetic production. It is compatible with a wide range of cosmetic ingredients.

     

    Structure of Natural Yeast Glucan and Carboxymethyl Glucan Structure and 13C Nuclear Magnetic Data (ppm)

     

    Yeast glucan facilitates the porcine keratinocyte growth of pigs

     

    Yeast glucan induces the production of macrophage inflammatory protein-2

     

    Protective effect of yeast glucan against UV irradiation

     

    Protective effect of yeast glucan against UV irradiation

    Protective effect of glucan preparations against the decline of human skin humidity caused by sodium dodecyl sulfate

     

    Protective effect of yeast glucan preparations against the squalene peroxidation of human skin

     

    Healing Effect of Glucan for Couperose Skin

    Healing Effect of Glucan for Rashes

     

    BioActive Nanomate

    Diagram of Nanomate Structure

    Description: BioActive Nanomate is a new and stable nano-carrier for cosmetic active matters. It is a nano-colloid with a structure of monolayer membrane, composed of lecithin and co-surfactant at a certain proportion. The average particle diameter is 20~40 nm. Nanomate is clear and transparent with the unique blue fluorescence of nano-emulsion, and it is suitable for transparent systems such as water and emulsion. Nanomate can form a closure effect on the surface of skin and improves the moisturizing performance of skin. Its unique nano-biological effect facilitates the stability and absorption of biological active matters to let them function better. Compared with traditional liposomes, Nanomate is with a smaller particle diameter, a more balanced diameter distribution, a higher transparency, and a more stable structure.

    Nanomate passes through the stratum corneum at a much higher rate and speed than normal liposomes, allowing the coated active matters to reach the deeper layers of the epidermis until it functions in the dermal tissue. Compared with other carriers of equal quality, Nanomate carries more active matters and can cover the skin better. Since it has a tapered stable structure of a co-surfactant embedded in the monolayer membrane nano-micelle formed by lecithin, it effectively hinders the exchange of the active substances in the nano-carrier core with other substances such as extranuclear surfactant, i.e., the destructive dissolution effect of something like surfactants towards the membrane of nano-carriers is effectively prevented. This enables Nanomate to maintain a high stability during formulation, storage, transportation and consumer use of cosmetics, and diffuse more effectively through the stratum corneum of skin to be absorbed or fused by epidermal cells.

     

     

     

     

     

     

     

     

     

     

     

     

    Liposome (100-300nm)                Nanomate (20-40nm)

     

    Compared with traditional emulsion, Nanomate is featured with a very small particle diameter and a strong adhesive effect. Nano-particles of Nanomate can form a good occlusion effect on the skin and improves the moisturizing performance of skin

    Occlusion Effect

    Compared with traditional large emulsion, nano-emulsion can penetrate to the depths of skin more easily.

    Nanomate can effectively promote the skin to absorb active matters

     

    Nanomate has a unique nano-effect that can effectively enhance the stability of the active matters in skincare formulations, thus helping maintain a sufficient content of active matters in skincare products during the shelf life. Nanomate can also effectively open up a channel for skin to absorb biological active matters and promote the absorption and function, thereby enhancing the efficacy of skincare products.

    The smaller the particle size, the deeper the penetration and the greater the amount

    Deeper and longer lasting (hair follicle storage for up to 10 days) with a unique hair follicle targeting

    Rice bran oil is rich in nutrients such as vitamin A, vitamin E, amino acids and niacin necessary for skin and hair. These substances are featured with a moisturizing function, which can effectively prevent skin dryness, delay skin aging and prevent pigmentation.

    Applications:

  • Skincare
  • Follicle care
  • Haircare
  • Bodycare
  • Facial care
  • Dry skin care
  • Winter skincare
  • Daily skincare
  • Products for sensitive skin
  • Product Use :add it at an ordinary temperature; recommended dosage: 1-10%. Better effect with bioactive products such as plant extracts.

    Storage: keep it away from light at a temperature lower than 25℃.

    Bio-Skinflora Solution

    Description: nutrient solution with strong capacities of moisture retention, soothing allergies and anti-irritation

    Innovative Mechanism:

    Plant collagen, glucan and prebiotics work together to form a highly hydrophilic micro-ecological protective membrane on the skin, which protects, repairs and strengthens the first defensive line for skin.

    With a strong hydrophilic feature, phytocollagen is a very good natural moisturizing ingredient. Unlike general covering moisturizer, Plant collagen can promote the keratinocytes of skin to produce a natural moisturizing factor (NMF), which exerts a moisturizing effect, penetrates and infiltrates the stratum corneum, making the skin more transparent and moisturized, and forming a skin self-protection mechanism. This will enhance skin elasticity, eliminate small wrinkles, improves the texture of skin, and isolates external toxic and harmful substances.

    The natural water-soluble yeast β-glucan can bind to the receptor CR3 of yeast β-glucan on the Langerhans cells in the epidermis, activate macrophages, and produce various cytokines (e.g., IL-1, IL-6, GM-CSF), epidermal growth factor (EGF), tumor necrosis factor (TNF-α) and angiogenic factors (AF), etc., thus improving skinimmunity. Yeast glucan also has the function of anti-inflammation, anti-allergy, eliminating free radical, moisturizing and accelerating stratum corneum renewal, which helps the skin resist external mechanical and chemical stimuli and facilitates the recovery of injuries. An increase in epidermal growth factor can promote the production of collagen and elastin, thus improving the exterior of skin and eliminating fine line wrinkles.

    Prebiotics promotes the growth of epidermal probiotics through selective nutrient supply mechanisms, inhibits the growth of harmful flora through competitive mechanisms, establishes and maintains a stable and healthy skin micro-ecological system, maintains healthy skin pH, and reduces inflammation and allergic reactions. .

     

     

     

     

     

     

     

    Fermentation-derived Phytocollagen

     

     

     

     

     

     

     

     

     

    Plant-derived Fructan and Fructose Oligomers

     

     

     

     

     

     

     

    Yeast-derived Glucan

     

    Prebiotics can improve skin micro-ecological balance

    Applications:

    1. Sensitive skin: protecting the skin from external stimuli, soothing allergies and anti-inflammation
    2. Dry skin: moisturizing, wrinkle-reducing, anti-aging, improving skin texture
    3. Anti-acne&pimple: inhibiting the growth of harmful microbes such as propionibacterium acnes, promoting the growth of skin probiotics, establishing a healthy micro-ecological system, and regulating the pH value of skin health.
    4. Infant care: prevention on infection (especially for the areas wrapped with diaper)
    5. Other skincare and haircare products.

     

    Instruction for Prescription

    Solubility: This product is easily soluble in water

    Recommended dosage: The product is added in an amount of 1-10%. It is recommended to add this below 60℃ in the final stage of cosmetic production. It is compatible with a wide range of cosmetic ingredients.

     

     

    Puri Platform Technology

    Biotechnology: Puripharm has established modern biotechnologies represented by the genetic engineering, metabolic engineering, protein engineering, fermentation engineering, biochemical extraction, etc. It is equipped with the ability to research, develop and produce biological active matters such as polypeptides, protein, carbohydrate, probiotics, ceramide and glycolipid. Biotechnology is featured with a high technical threshold, good product quality, strong biological activity, environmental friendliness, etc. It is the trend and method for the R&D and production of biological active matters.

     

    Plant Extraction: Plant resource represented by traditional Chinese medicine and natural drugs is a huge treasure trove of biological active matters. Puripharm has established a discovery and screening system for new biological activity in cooperation with domestic and foreign research institutions and pharmaceutical companies. It has also set up separation and purification, large-scale production and quality control methods such as carbon dioxide supercritical extraction, liquid chromatography, freeze drying and LC-MS.

     

    Green Chemistry: The goal of green chemistry is to reduce the impact of chemicals on human health with a dedicated sustainable prevention program, reduce or eliminate the use of chemicals and the production of hazardous substances in the design of chemical substances, thus effectively getting rid of environmental pollution. Green chemistry is constantly looking for alternative environmental friendly reaction media while trying to increase the reaction rate and lower the reaction temperature. Green chemistry solves environmental problems in the production of biological active matters by applying innovative scientific solutions. Green chemistry will play an increasingly important role in the sustainable development of biological active matters.

     

    Innovative Formulation:There is a growing number of biological active matters that face the problems such as being difficult to dissolve, unstability, being easy to be discolored, and low bio-availability during the development of new products. Puripharm has developed innovative formulation methods represented by Nano-Delivery System, Smart Gel System, Transdermal Delivery System, and Bioadhesive Delivery System, which can be widely applied to the development of new drugs and biological active matters to improve product effectiveness, safety, stability and applicability, thereby effectively increasing product performance and added value.”